NOC:Organic Chemistry in Biology and Drug Development

Lecture 1 - A brief introduction to Molecules of Life: Structure of Amino acids and their various charged forms

Lecture 2 - Biological Macromolecules and Small molecules: Importance and functions

Lecture 3 - Amino Acids: The building block of proteins

Lecture 4 - Amino acids: separation and detection, Electrophoresis and Ninhydrin reaction

Lecture 5 - Method of determination of Amino acid sequence: primary structure of polypeptide/protein

Lecture 6 - Selective peptide bond cleavage: Enzymatic and Non-enzymatic methods

Lecture 7 - Peptide synthesis: Protecting groups for amine and carboxyl functionality

Lecture 8 - Peptide synthesis (Continued...) Protection, coupling and deprotection method

Lecture 9 - Recent development of coupling agents; Merrifield’s method of solid phase peptide synthesis

Lecture 10 - Hierarchial structure of proteins: Secondary, tertiary and quaternary structure

Lecture 11 - Ramachandran plot and protein purification techniques

Lecture 12 - Protein purification techniques (Continued...)

Lecture 13 - Introduction to Enzymes and its kinetics

Lecture 14 - Enzyme catalysed reactions and introduction to catalytic activity of proteases

Lecture 15 - Enzyme Kinetics (Continued...)

Lecture 16 - Concept of Enzyme Inhibition

Lecture 17 - Concept of Enzyme Inhibition (Continued...)

Lecture 18 - Problems on Enzyme Kinetics and Enzyme Inhibition

Lecture 19 - Synthetic Biology

Lecture 20 - Synthetic Biology (Continued...)

Lecture 21 - Synthetic Biology (Continued...)

Lecture 22 - Nucleic Acid

Lecture 23 - Nucleic Acid (Continued...)

Lecture 24 - DNA sequencing method

Lecture 25 - DNA sequencing method (Continued...)

Lecture 26 - DNA sequencing method (Continued...)

Lecture 27 - Synthesis of oligonucleotide

Lecture 28 - Central dogma: DNA replication, transcription and translation

Lecture 29 - Central dogma: DNA replication, transcription and translation (Continued...)

Lecture 30 - Central dogma: DNA replication, transcription and translation (Continued...)

Lecture 31 - Central dogma: DNA replication, transcription and translation (Continued...)

Lecture 32 - Central dogma: DNA replication, transcription and translation (Continued...)

Lecture 33 - Molecular Biology

Lecture 34 - Molecular Biology (Continued...)

Lecture 35 - Chemistry of cofactors/coenzymes

Lecture 36 - Chemistry of cofactors/coenzymes (Continued...)

Lecture 37 - Chemistry of cofactors/coenzymes (Continued...)

Lecture 38 - Chemistry of cofactors/coenzymes (Continued...)

Lecture 39 - Chemistry of cofactors/coenzymes (Continued...)

Lecture 40 - Chemistry of cofactors/coenzymes (Continued...)

Lecture 41 - Introduction to Drug Discovery Process

Lecture 42 - Fundamental Principles of Drug Development Process

Lecture 43 - Combinatorial chemistry

Lecture 44 - Neurotransmitters

Lecture 45 - Catechol amine based and GABA neurotransmitters

Lecture 46 - Hypertension: humoral mechanism and renin/angiotensin system

Lecture 47 - Inhibitor design of angiotensin converting enzyme

Lecture 48 - Antimicrobial drugs

Lecture 49 - Chemistry of penicillins

Lecture 50 - Resistance to beta-lactam antibiotics

Lecture 51 - Mechanistic studies of beta-lactamase

Lecture 52 - Non beta-lactam antibiotics

Lecture 53 - Mechanistic enzymology of Isopenicillin N synthase

Lecture 54 - Polyketide Biosynthesis

Lecture 55 - Biosynthesis of macrolide polyketides and introduction to virus

Lecture 56 - Anti-viral drugs

Lecture 57 - Cancer and Chemotherapy

Lecture 58 - Anti-cancer drugs (Continued...)

Lecture 59 - Aromatase inhibition and Anti-ulcer drugs

Lecture 60 - Cholesterol lowering agents

Lecture 61 - Cholesterol Biosynthesis

Lecture 62 - Pharmakinetics and pharmadynamics

Lecture 63 - QSAR principles