NOC:Chemical and Biological Thermodynamics - Principles to Applications

Lecture 1 - Fundamentals of Chemical thermodynamics

Lecture 2 - Work

Lecture 3 - Tutorial-1

Lecture 4 - First Law of Thermodynamics

Lecture 5 - Tutorial-2

Lecture 6 - Adiabatic processes

Lecture 7 - Entropy

Lecture 8 - Entropy and Second Law: Basics

Lecture 9 - Entropy and Second Law: Applications

Lecture 10 - Third Law of Thermodynamics

Lecture 11 - Discussion on Helmholtz energy

Lecture 12 - Discussion on Gibbs Energy

Lecture 13 - Maxwell relations, Properties of Gibbs energy

Lecture 14 - Further discussion on properties of Gibbs energy

Lecture 15 - Fugacity

Lecture 16 - Tutorial session

Lecture 17 - Tutorial session

Lecture 18 - Chemical potential of a substance in mixture

Lecture 19 - Chemical potential of Liquids, Raoult’s Law, Henry’s Law

Lecture 20 - Thermodynamics of mixing, Excess functions

Lecture 21 - Partial molar volume

Lecture 22 - Activities (Accounting for deviations from Ideal behaviour)

Lecture 23 - Tutorial on thermodynamics of mixing and deviations from ideality

Lecture 24 - Further discussion on relation between C p and C v

Lecture 25 - Chemical Equilibrium

Lecture 26 - Perfect gas equilibria

Lecture 27 - Equilibrium constant

Lecture 28 - Effect of pressure on equilibrium constant and equilibrium composition

Lecture 29 - Effect of temperature on equilibria

Lecture 30 - Biological standard states and pH

Lecture 31 - Tutorial 1 - Equilibrium constant

Lecture 32 - Tutorial 2 - Equilibrium constant

Lecture 33 - Acids and bases and Equilibrium concepts

Lecture 34 - pH Scale Strong and weak acids and bases

Lecture 35 - Strong and weak acids and bases

Lecture 36 - Acid-base titrations

Lecture 37 - pH curve for titration of weak acid with strong base Buffers and indicators

Lecture 38 - Thermodynamics in systems of biological interest

Lecture 39 - Calorimetry

Lecture 40 - Differential scanning calorimetry (DSC)

Lecture 41 - Further discussion on Differential Scanning Calorimetry (DSC)

Lecture 42 - Explaining Differential Scanning Calorimetric Profiles (DSC Profiles)

Lecture 43 - Applications of DSC in thermal unfolding of proteins and protein-solvent interactions

Lecture 44 - Further discussion on applications of DSC in thermal unfolding of proteins and protein-solvent interactions

Lecture 45 - Isothermal Titration calorimetry (ITC)

Lecture 46 - Further discussion on Isothermal Titration calorimetry (ITC)

Lecture 47 - ITC Experimental Design and Isothermal Titration Calorimetry (ITC) in Drug Design

Lecture 48 - Isothermal Titration Calorimetry (ITC) in Drug Design

Lecture 49 - Isothermal Titration Calorimetry (ITC) in Engineering Binding Affinity

Lecture 50 - Calorimetry in identifying partially folded states of proteins (Molten Globule State)

Lecture 51 - Thermodynamic Characterization of Partially Folded States of Proteins

Lecture 52 - Quantitative Thermodynamic Characterization of Partially Folded States of Proteins

Lecture 53 - ITC in Drug-Protein Interactions

Lecture 54 - Identifying sites for Drug-Protein Interactions by ITC

Lecture 55 - Identifying sites for Drug-Protein Interactions, DSC of Protein-Ligand Complexes. Enthalpy-Entropy Compensation

Lecture 56 - Estimation of Binding Constants in Strong to Ultratight Protein-Ligand, Interactions Using Differential Scanning Calorimetry

Lecture 57 - Continuation of discussion on... Estimation of Binding Constants in Strong to UltratightProtein-Ligand Interactions Using Differential Scanning Calorimetry

Lecture 58 - Thermal unfolding of protein by non-calorimetric methods, Addressing thermodynamics of the process

Lecture 59 - Titration Calorimetry as a tool to determine thermodynamic and Kinetic parameters of enzymes

Lecture 60 - Summary of the course